2-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol → HCID 178423505, compound

HRID 31697Notes

Reaction equation

HRID 31697 reaction equation
[Na].C(C1(CCOC2C=CN=C(C[S:24]([C:26]3[NH:30][C:29]4[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=4[N:27]=3)=O)C=2C)OCC2(OCCO2)CO1)C.[CH3:36]C1(CCO)OCC2(OCCO2)CO1>>[CH3:36][C:33]1[CH:32]=[CH:31][C:29]2[NH:30][C:26]([SH:24])=[N:27][C:28]=2[CH:34]=1

Participants

3

Reactant 2

HCID 597925642-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanolHCID 667761962-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 178423505HCID 178423505, compound

Procedure

The same procedure as in the steps (4f) to (4j) of Example 4 was repeated using 2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol obtained in the step (73b) above and 5-methyl-1H-benzimidazole-2-thiol obtained in the step (47a) to obtain the title compound (188 mg, total 12.4% yield) as a white solid.

Sources & evidence

ORD record
ord-0f4626bceb324bd59caca4aeaab20747
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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