(4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methanol → HCID 178527753, compound

HRID 31701Notes

Reaction equation

HRID 31701 reaction equation
[Na].CC1C(C[S:23]([C:25]2[NH:29][C:28]3[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=3[N:26]=2)=O)=NC=CC=1OCC1(C)OCC2(OCCO2)CO1.C[C:35]1(C)[O:40]CC(COC2C=CN=C(CO)C=2C)C[O:36]1>>[O:36]1[C:31]2[C:32](=[CH:33][C:27]3[NH:26][C:25]([SH:23])=[N:29][C:28]=3[CH:30]=2)[O:40][CH2:35]1

Participants

3

Reactant 2

HCID 59792349(4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methanolHCID 667765502-(((3-Methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 178527753HCID 178527753, compound

Procedure

The same procedure as in the steps (5f) to (5h) of Example 5 was repeated using (4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methanol obtained in the step (12b) above and 5H-[1,3]dioxolo[4,5-f]benzimidazole-6-thiol obtained in the step (78c) above to obtain the title compound (347 mg, total 51.9% yield) as a white solid.

Sources & evidence

ORD record
ord-c4c0355f48e248f0b99d7974039fac8f
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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