1,4-Dioxaspiro[4.5]decan-8-ylmethanol → 2-(((4-(1,4-Dioxaspiro[4.5]dec-8-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Participants

Role	Name	HCID	Charge
Reactant	1,4-Dioxaspiro[4.5]decan-8-ylmethanol	HCID 10080838	—
Reactant	(4-(((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-methylpyridin-2-yl)methanol	HCID 57823107	—
Reactant	2-(((4-((2,2-Bis(fluoromethyl)-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt	HCID 66775767	—
Product	2-(((4-(1,4-Dioxaspiro[4.5]dec-8-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt	HCID 66776331	—

Reaction Steps

The same procedure as in the steps (14a) to (14b) of Example 14 and the steps (7d) to (7f) of Example 7 was repeated using the 1,4-dioxaspiro[4.5]dec-8-ylmethanol obtained in the step (82a) above to obtain the title compound (115 mg, the total yield of 5 steps: 7.3%) as a white solid. Note that, in the same process as in the step (14b), after acetic anhydride was added, 2 equivalents of triethylamine relative to pyridine1-oxide derivative was added to perform the reaction.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07425634B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-321f1cbbd0cd4e728345bc492c738254
Source note	uspto-grants-2008_09