Acetic Acid → N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3'-fluoro-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

HRID 317120Notes

Reaction equation

HRID 317120 reaction equation
[C:49]([O:50][BH-:51]([O:52][C:53](=[O:54])[CH3:55])[O:56][C:57](=[O:58])[CH3:59])(=[O:60])[CH3:61].[CH2:39]1[CH2:40][O:41][CH2:42][CH2:43][NH:44]1.[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[cH:15][c:16](-[c:30]3[cH:31][c:32]([F:38])[c:33]([CH:36]=[O:37])[cH:34][cH:35]3)[cH:17][c:18]([N:21]([CH:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[CH2:28][CH3:29])[c:19]2[CH3:20])[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1.[CH3:45][C:46](=[O:47])[OH:48].[Cl:63][CH:64]([Cl:65])[CH3:66].[Cl:67][CH2:68][Cl:69].[Na+:62]>>[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[cH:15][c:16](-[c:30]3[cH:31][c:32]([F:38])[c:33]([CH2:36][N:44]4[CH2:39][CH2:40][O:41][CH2:42][CH2:43]4)[cH:34][cH:35]3)[cH:17][c:18]([N:21]([CH:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[CH2:28][CH3:29])[c:19]2[CH3:20])[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 923Sodium ionHCID 6344DichloromethaneHCID 63651,1-DichloroethaneHCID 8083MorpholineHCID 2724942TriacetoxyborohydrideHCID 86672657N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3'-fluoro-4'-formyl-4-methyl-[1,1'-biphenyl]-3-carboxamide

Product 1

HCID 70872483N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3'-fluoro-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

Sources & evidence

ORD record
ord-1618ae5b900d41cba983f794624348bc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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