(4-(5,7-Dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methanol → HCID 66776693, compound

HRID 31719Notes

Reaction equation

HRID 31719 reaction equation
[Na:1].[CH3:2][C:3]1[C:4]([CH2:22][S:23]([C:25]2[NH:29][C:28]3[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=3[N:26]=2)=[O:24])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1(C)[O:20][CH2:19][C:14]2(OCCO2)[CH2:13][O:12]1.C1C2(CO[CH:39]([CH2:42][O:43]C3C=CN=C(CO)C=3C)[O:38]C2)C1.N1[C:57]2C=C3OCCOC3=C[C:56]=2N=C1S>>[Na:1].[CH2:56]1[C:14]2([CH2:19][O:20][CH:11]([CH2:10][O:9][C:8]3[CH:7]=[CH:6][N:5]=[C:4]([CH2:22][S:23]([C:25]4[NH:29][C:28]5[CH:30]=[C:31]6[O:43][CH2:42][CH2:39][O:38][C:32]6=[CH:33][C:27]=5[N:26]=4)=[O:24])[C:3]=3[CH3:2])[O:12][CH2:13]2)[CH2:57]1

Participants

4

Reactant 3

HCID 59792562(4-(5,7-Dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methanolHCID 667765502-(((3-Methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltHCID 178527752HCID 178527752, compound

Product 1

HCID 66776693HCID 66776693, compoundYield 55.6%

Procedure

The same procedure as in the steps (5f) to (5h) was repeated using the (4-(5,7-dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methanol obtained in Example (2d) and 6,7-dihydro-1H-[1,4]dioxino[2′,3′:4,5]benzo[d]imidazole-2-thiol to obtain the title compound (364 mg, total 55.6% yield) as a light pink solid.

Sources & evidence

ORD record
ord-adfc39449c7548449c892d36cfaf173b
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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