(4-(2,2-Dimethyl-1,3-dioxan-5-yl)methoxy-3,5-dimethylpyridin-2-yl)methanol monohydrate → (4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methanol

HRID 31725Notes

Reaction equation

HRID 31725 reaction equation
O.[CH3:2][C:3]1([CH3:21])[O:8][CH2:7][CH:6]([CH2:9][O:10][C:11]2[C:16]([CH3:17])=[CH:15][N:14]=[C:13]([CH2:18][OH:19])[C:12]=2[CH3:20])[CH2:5][O:4]1>C1(C)C=CC=CC=1>[CH3:2][C:3]1([CH3:21])[O:8][CH2:7][CH:6]([CH2:9][O:10][C:11]2[C:16]([CH3:17])=[CH:15][N:14]=[C:13]([CH2:18][OH:19])[C:12]=2[CH3:20])[CH2:5][O:4]1

Participants

3

Reactant 1

HCID 57445207(4-(2,2-Dimethyl-1,3-dioxan-5-yl)methoxy-3,5-dimethylpyridin-2-yl)methanol monohydrate

Product 1

HCID 57445208(4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methanol

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent3×

Procedure

To (4-(2,2-dimethyl-1,3-dioxan-5-yl)methoxy-3,5-dimethylpyridin-2-yl)methanol monohydrate (690 g), toluene was added to perform azeotropic dehydration (2.1 L×5, 1.75 L×1). To the concentrated product obtained, toluene (393 mL) was added to obtain a toluene solution (921 g) of (4-(2,2-dimethyl-1,3-dioxan-5-yl)methoxy-3,5-dimethylpyridin-2-yl)methanol.

Workup

  1. customTo the concentrated product obtained

Sources & evidence

ORD record
ord-f022d59f150b4a83a791dea7fd63e050
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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