反应详情

To a mixture of (4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl methanesulfonate (500 mg, 1.39=mmol), 2-mercaptobenzimidazole (209 mg, 1.39 mmol) and tetrahydrofuran (5 ml), triethylamine (0.387 ml, 2.78 mmol) was added and the mixture was stirred at room temperature for 14 hours and 25 minutes. The reaction mixture was concentrated under reduced pressure, and toluene and a 0.1N aqueous sodium hydroxide solution were added to the residue and insoluble substance was removed by filtration. The organic layer was taken out and the aqueous layer was extracted again with toluene. The organic layers were combined, washed with a saturated saline solution, dried over sodium sulfate, and filtrated. The filtrate was concentrated under reduced pressure. The residue was dissolved in n-heptane/ethyl acetate (1/1) and subjected to silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=1/1→0/1) to obtain the title compound (549 mg, 95.5%) as a colorless viscous oil.

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure, and toluene
3. additiona 0.1N aqueous sodium hydroxide solution were added to the residue and insoluble substance
4. customwas removed by filtration
5. extractionthe aqueous layer was extracted again with toluene
6. washwashed with a saturated saline solution
7. dry with materialdried over sodium sulfate
8. filtrationfiltrated
9. concentrationThe filtrate was concentrated under reduced pressure
10. dissolutionThe residue was dissolved in n-heptane/ethyl acetate (1/1)
11. washsubjected to silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=1/1→0/1)