2-(Bromomethyl)tetrahydro-2H-pyran → 1'-[(5-chloro-2-thienyl)methyl]-7'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 317384Notes

Reaction equation

HRID 317384 reaction equation
[Br:9][CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][O:16]1.[Cl:1][c:2]1[s:3][c:4]([CH2:7][Cl:8])[cH:5][cH:6]1.[F:17][C:18]([c:19]1[cH:20][cH:21][cH:22][c:23]2[c:24]1[NH:25][C:26](=[O:39])[C:27]21[CH2:28][O:29][c:30]2[c:31]1[cH:32][c:33]1[c:34]([cH:38]2)[O:35][CH2:36][O:37]1)([F:40])[F:41]>>[Cl:1][c:2]1[s:3][c:4]([CH2:7][N:25]2[c:24]3[c:19]([C:18]([F:17])([F:40])[F:41])[cH:20][cH:21][cH:22][c:23]3[C:27]3([C:26]2=[O:39])[CH2:28][O:29][c:30]2[c:31]3[cH:32][c:33]3[c:34]([cH:38]2)[O:35][CH2:36][O:37]3)[cH:5][cH:6]1

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 685972007'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 593521971'-[(5-chloro-2-thienyl)methyl]-7'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-d23d087079d34437822d74744bfc4023
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…