反应详情

A mixture of 0.161 g (0.46 mmol) of 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3 -d]pyrimidin-7-ylideneamine from Example 19 and 1.0 mL of acetic anhydride was heated to solution at the boiling point. After 2 minutes of reflux, the solution was concentrated to one-half volume, whereupon crystals formed. The mixture was cooled, 2 mL of ether was added, and the product was filtered and washed with ether; mp 229°-231° C.

1. temperaturewas heated to solution at the boiling point
2. temperatureAfter 2 minutes of reflux
3. concentrationthe solution was concentrated to one-half volume, whereupon crystals
4. customformed
5. temperatureThe mixture was cooled
6. filtrationthe product was filtered
7. washwashed with ether