反应详情

2,4-Dichlorophenacyl chloride (1.42 g, 6.4 mmol) and imidazole (1.18 g, 16 mmol) were heated in toluene (40 ml) at 75° C. for 2.25 hours. The mixture was concentrated to dryness in vacuo. The residue was dissolved in dichloromethane and washed with 5% aqueous potassium carbonate solution and water, dried and concentrated in vacuo. The crude product was purified by passage over a pad of silica gel, eluting with 5% methanol in dichloromethane to give 1-(2,4-dichlorophenyl)-2-imidazolylethan-1-one as an orange oil.

1. concentrationThe mixture was concentrated to dryness in vacuo
2. dissolutionThe residue was dissolved in dichloromethane
3. washwashed with 5% aqueous potassium carbonate solution and water
4. customdried
5. concentrationconcentrated in vacuo
6. customThe crude product was purified by passage over a pad of silica gel
7. washeluting with 5% methanol in dichloromethane