Morpholine → Ethyl 4-(4-cyanophenyl)-2-[(2-{[5-(morpholin-4-ylcarbonyl) (2-pyridyl)]amino}ethyl)amino]pyrimidine-5-carboxylate

HRID 31755Notes

Reaction equation

HRID 31755 reaction equation
Cl[C:2]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][CH2:11][CH2:12][NH:13][C:14]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)[C:17]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:16][N:15]=2)=[N:8][CH:9]=1)=[O:3].[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>ClCCl>[C:26]([C:23]1[CH:24]=[CH:25][C:20]([C:18]2[C:17]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:16][N:15]=[C:14]([NH:13][CH2:12][CH2:11][NH:10][C:7]3[CH:6]=[CH:5][C:4]([C:2]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][CH2:34]4)=[O:3])=[CH:9][N:8]=3)[N:19]=2)=[CH:21][CH:22]=1)#[N:27]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 22142924HCID 22142924, compound

Product 1

HCID 22142703Ethyl 4-(4-cyanophenyl)-2-[(2-{[5-(morpholin-4-ylcarbonyl) (2-pyridyl)]amino}ethyl)amino]pyrimidine-5-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

The solution of ethyl 2-({2-[(5-(chlorocarbonyl)(2-pyridyl))amino]ethyl}amino)-4-(4-cyanophenyl)pyrimidine-5-carboxylate in dichloromethane prepared in Step 1 of Example 71 (1.0 ml) was treated at room temperature with a solution of morpholine (150 μL) in dichloromethane (1 ml). After 1 hour the solvent was removed in vacuo to give the title compound.

Workup

  1. customAfter 1 hour the solvent was removed in vacuo

Sources & evidence

ORD record
ord-c83eb3354538473ba1a0ad848f2fd5cd
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

Loading…