Potassium Cation → 7-Oxo-5-phenyl-N-{3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl}-7H-thieno[3,2-b]pyran-3-carboxamide

HRID 317719Notes

Reaction equation

HRID 317719 reaction equation
[C:42](=[O:43])([O-:44])[O-:45].[Cl:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:7])[c:8]1[cH:9][s:10][c:11]2[c:12]1[o:13][c:14](-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[cH:15][c:16]2=[O:17].[F:24][C:25]([CH2:26][O:27][c:28]1[c:29]([N:34]2[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]2)[cH:30][cH:31][cH:32][cH:33]1)([F:40])[F:41].[K+:46].[K+:47]>>[CH2:2]([CH2:3][CH2:4][NH:5][C:6](=[O:7])[c:8]1[cH:9][s:10][c:11]2[c:12]1[o:13][c:14](-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[cH:15][c:16]2=[O:17])[N:37]1[CH2:36][CH2:35][N:34]([c:29]2[c:28]([O:27][CH2:26][C:25]([F:24])([F:40])[F:41])[cH:33][cH:32][cH:31][cH:30]2)[CH2:39][CH2:38]1

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 22464456N-(3-Chloropropyl)-7-oxo-5-phenyl-7H-thieno[3,2-b]pyran-3-carboxamide

Product 1

HCID 99379847-Oxo-5-phenyl-N-{3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl}-7H-thieno[3,2-b]pyran-3-carboxamide

Sources & evidence

ORD record
ord-d33d5c52b3a64f80b2d059fe58a1881c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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