HRID31798

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

结构：Nc1nc(NCCNc2ncc(N3C(=O)C=CC3=O)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-]

HCID22143089

未命名化合物

PRODUCTS

生成物

结构：Nc1nc(NCCNc2ncc(N3C(=O)CC(N4CCOCC4)C3=O)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-]

HCID9894980

未命名化合物

PROCEDURE

实验过程

Large excess of morpholine was added to clean fractions of 1-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-3-pyrroline-2,5-dione concentrated in vacuo, and purified by column chromatography eluting with 5-10% methanol/methylene chloride to obtain 1-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]-ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-3-morpholin-4-ylpyrrolidine-2,5-dione.

WORKUP

后处理

concentrationconcentrated in vacuo
custompurified by column chromatography
washeluting with 5-10% methanol/methylene chloride

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07c90b2cbf0e44bc832c93993924e49d
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07425557B2
来源说明: uspto-grants-2008_09

反应 SMILES

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:7][C:8]1[N:13]=[C:12]([NH:14][CH2:15][CH2:16][NH:17][C:18]2[N:23]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[Cl:31])[C:21]([N:32]3[C:36](=[O:37])[CH:35]=[CH:34][C:33]3=[O:38])=[CH:20][N:19]=2)[CH:11]=[CH:10][C:9]=1[N+:39]([O-:41])=[O:40]>>[NH2:7][C:8]1[N:13]=[C:12]([NH:14][CH2:15][CH2:16][NH:17][C:18]2[N:23]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[Cl:31])[C:21]([N:32]3[C:36](=[O:37])[CH2:35][CH:34]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)[C:33]3=[O:38])=[CH:20][N:19]=2)[CH:11]=[CH:10][C:9]=1[N+:39]([O-:41])=[O:40]