Acetic Acid → Racemic ((3RS,4SR)-4-Amino-4-(5-bromo-2-fluorophenyl)tetrahydrofuran-3-yl)methanol

HRID 318369Notes

Reaction equation

HRID 318369 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:16])[c:6]([C:8]23[NH:9][O:10][CH2:11][CH:12]2[CH2:13][O:14][CH2:15]3)[cH:7]1.[CH3:17][C:18](=[O:19])[OH:20].[Zn:21]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:16])[c:6]([C:8]2([NH2:9])[CH:12]([CH2:11][OH:10])[CH2:13][O:14][CH2:15]2)[cH:7]1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 23994ZincHCID 57475807Racemic (3aSR,6aSR)-6a-(5-Bromo-2-fluorophenyl)hexahydrofuro[3,4-c]isoxazole

Product 1

HCID 66847662Racemic ((3RS,4SR)-4-Amino-4-(5-bromo-2-fluorophenyl)tetrahydrofuran-3-yl)methanol

Sources & evidence

ORD record
ord-704f8afcb5704f45b246f083c52aef17
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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