2-Chloro-4-fluorobenzoyl chloride → HCID 22142910, compound

HRID 31888Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=O.Cl[C:13]1[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][N:14]=1.ClC1C=C(Cl)C=CC=1C1[C:34]([C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)=[CH:33][N:32]=[C:31]([NH:40][CH2:41][CH2:42][NH:43]C2C=CC([N+]([O-])=O)=CN=2)[N:30]=1>>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]1[C:34]([C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)=[CH:33][N:32]=[C:31]([NH:40][CH2:41][CH2:42][NH:43][C:13]2[N:14]=[CH:15][C:16]([C:19]#[N:20])=[CH:17][CH:18]=2)[N:30]=1

Participants

Reactant 3

HCID 27365462-Chloro-4-fluorobenzoyl chloride

HCID 51520946-Chloro-3-pyridinecarbonitrile

HCID 9847557Chir-98023

Product 1

HCID 22142910HCID 22142910, compound

Procedure

6-[(2-{[4-(2-chloro-4-fluorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}ethyl)-amino]pyridine-3-carbonitrile was prepared from 2-chloro-4-fluorobenzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record: ord-8e62642c84664386b1bcbcfb0093a882
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07425557B2

Reaction notes

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