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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31890Generated: October 26, 2026

4-Fluoro-2-(trifluoromethyl)benzoyl chloride → 6-{[2-({4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile

https://huagongshe.com/reaction/31890

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 605680—
Reactant6-Chloro-3-pyridinecarbonitrileHCID 5152094—
ReactantChir-98023HCID 9847557—
Product6-{[2-({4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrileHCID 22143088—

Reaction Steps

6-{[2-({4-[4-fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile was prepared from 4-fluoro-2-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425557B2
Source datasetuspto-grants-2008_09
ORD IDord-b7597be2bc6c4cdcbeb2cd08a6838035
Source noteuspto-grants-2008_09