5-Cyanopyridine-3-carboxylic acid → N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-cyanonicotinamide

HRID 318914Notes

Reaction equation

HRID 318914 reaction equation
[C:22](#[N:23])[c:24]1[cH:25][c:26]([C:30](=[O:31])[OH:32])[cH:27][n:28][cH:29]1.[Cl:1][c:2]1[c:3]([CH3:21])[cH:4][c:5](-[c:8]2[cH:9][c:10]([NH2:20])[cH:11][n:12][c:13]2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([CH3:21])[cH:4][c:5](-[c:8]2[cH:9][c:10]([NH:20][C:30]([c:26]3[cH:25][c:24]([C:22]#[N:23])[cH:29][n:28][cH:27]3)=[O:31])[cH:11][n:12][c:13]2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 221747825-Cyanopyridine-3-carboxylic acidHCID 672811395-(4-Chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56962108N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-cyanonicotinamide

Sources & evidence

ORD record
ord-fd2652c4cb4f420387dc0ec79968b09b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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