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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31897Generated: October 25, 2026

2-Fluoro-4-(trifluoromethyl)benzoyl chloride → 6-{[2-({4-[2-Fluoro-4-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile

https://huagongshe.com/reaction/31897

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-(trifluoromethyl)benzoyl chlorideHCID 145580—
Reactant6-Chloro-3-pyridinecarbonitrileHCID 5152094—
ReactantChir-98023HCID 9847557—
Product6-{[2-({4-[2-Fluoro-4-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrileHCID 22143005—

Reaction Steps

6-{[2-({4-[2-fluoro-4-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile was prepared from 2-fluoro-4-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425557B2
Source datasetuspto-grants-2008_09
ORD IDord-ff3164a08e7c405abae323144533f98f
Source noteuspto-grants-2008_09