Chir-98023 → [4-(4-Chloro-2-methoxyphenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

HRID 31900Notes

Reaction equation

HRID 31900 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([O:11][CH3:12])[CH:3]=1.ClC1C=C(Cl)C=CC=1C1[C:26]([C:27]2[NH:28][CH:29]=[CH:30][N:31]=2)=[CH:25][N:24]=[C:23]([NH:32][CH2:33][CH2:34][NH:35][C:36]2[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[CH:38][N:37]=2)[N:22]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:26]([C:27]3[NH:31][CH:30]=[CH:29][N:28]=3)=[CH:25][N:24]=[C:23]([NH:32][CH2:33][CH2:34][NH:35][C:36]3[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[CH:38][N:37]=3)[N:22]=2)=[C:4]([O:11][CH3:12])[CH:3]=1

Participants

3

Reactant 2

HCID 9847557Chir-98023HCID 221424504-Chloro-2-methoxybenzoyl chloride

Product 1

HCID 22143096[4-(4-Chloro-2-methoxyphenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

Procedure

[4-(4-chloro-2-methoxyphenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine was prepared from 4-chloro-2-methoxybenzoyl chloride using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-77763e24b0bf4dba87212165e72d0f72
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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