6-Chloro-3-pyridinecarbonitrile → 6-[(2-{[4-(4-Chloro-2-methoxyphenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}-ethyl)amino]pyridine-3-carbonitrile

HRID 31901Notes

Reaction equation

HRID 31901 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([O:11][CH3:12])[CH:3]=1.Cl[C:14]1[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][N:15]=1.ClC1C=C(Cl)C=CC=1C1[C:35]([C:36]2[NH:37][CH:38]=[CH:39][N:40]=2)=[CH:34][N:33]=[C:32]([NH:41][CH2:42][CH2:43][NH:44]C2C=CC([N+]([O-])=O)=CN=2)[N:31]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:35]([C:36]3[NH:37][CH:38]=[CH:39][N:40]=3)=[CH:34][N:33]=[C:32]([NH:41][CH2:42][CH2:43][NH:44][C:14]3[N:15]=[CH:16][C:17]([C:20]#[N:21])=[CH:18][CH:19]=3)[N:31]=2)=[C:4]([O:11][CH3:12])[CH:3]=1

Participants

4

Reactant 3

HCID 51520946-Chloro-3-pyridinecarbonitrileHCID 9847557Chir-98023HCID 221424504-Chloro-2-methoxybenzoyl chloride

Product 1

HCID 221430666-[(2-{[4-(4-Chloro-2-methoxyphenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}-ethyl)amino]pyridine-3-carbonitrile

Procedure

6-[(2-{[4-(4-chloro-2-methoxyphenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}-ethyl)amino]pyridine-3-carbonitrile was prepared from 4-chloro-2-methoxybenzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-a8faa2e9ef8449eaa429ddd5da92288b
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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