6-Chloro-3-pyridinecarbonitrile → HCID 22142706, compound

HRID 31903Notes

Reaction equation

HRID 31903 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([Cl:11])[CH:3]=1.Cl[C:13]1[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][N:14]=1.ClC1C=C(Cl)C=CC=1C1[C:34]([C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)=[CH:33][N:32]=[C:31]([NH:40][CH2:41][CH2:42][NH:43]C2C=CC([N+]([O-])=O)=CN=2)[N:30]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:34]([C:35]3[NH:36][CH:37]=[CH:38][N:39]=3)=[CH:33][N:32]=[C:31]([NH:40][CH2:41][CH2:42][NH:43][C:13]3[N:14]=[CH:15][C:16]([C:19]#[N:20])=[CH:17][CH:18]=3)[N:30]=2)=[C:4]([Cl:11])[CH:3]=1

Participants

4

Reactant 3

HCID 51520946-Chloro-3-pyridinecarbonitrileHCID 9847557Chir-98023HCID 155922074-Bromo-2-chlorobenzoyl chloride

Product 1

HCID 22142706HCID 22142706, compound

Procedure

6-[(2-{[4-(4-bromo-2-chlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}ethyl)-amino]pyridine-3-carbonitrile was prepared from 4-bromo-2-chlorobenzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-18cac9e7435b4a348f886f49ed2ee864
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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