2-Chloro-5-(trifluoromethyl)pyridine → HCID 22142406, compound

HRID 31904Notes

Reaction equation

HRID 31904 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([Cl:11])[CH:3]=1.Cl[C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][N:14]=1.ClC1C=C(Cl)C=CC=1C1[C:36]([C:37]2[NH:38][CH:39]=[CH:40][N:41]=2)=[CH:35][N:34]=[C:33]([NH:42][CH2:43][CH2:44][NH:45]C2C=CC([N+]([O-])=O)=CN=2)[N:32]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:36]([C:37]3[NH:38][CH:39]=[CH:40][N:41]=3)=[CH:35][N:34]=[C:33]([NH:42][CH2:43][CH2:44][NH:45][C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][N:14]=3)[N:32]=2)=[C:4]([Cl:11])[CH:3]=1

Participants

4

Reactant 3

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 9847557Chir-98023HCID 155922074-Bromo-2-chlorobenzoyl chloride

Product 1

HCID 22142406HCID 22142406, compound

Procedure

[4-(4-bromo-2-chlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl](2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine was prepared from 4-bromo-2-chlorobenzoyl chloride and 2-chloro-5-(trifluoromethyl)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-504a36f4e022415b8c5abe2889a1680e
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

Loading…