[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine → [5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

HRID 319053Notes

Reaction equation

HRID 319053 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][n:11][c:12]([NH:14][c:15]3[cH:16][cH:17][c:18]([O:21][CH2:22][CH2:23][N:24]4[CH2:25][CH2:26][CH2:27][CH2:28]4)[cH:19][cH:20]3)[s:13]2)[cH:7][cH:8]1.[CH3:29][N:30]1[CH2:31][CH2:32][N:33]([c:36]2[cH:37][cH:38][c:39]([NH:40][C:41]([NH2:42])=[S:43])[cH:44][cH:45]2)[CH2:34][CH2:35]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][n:11][c:12]([NH:14][c:15]3[cH:16][cH:17][c:18]([N:33]4[CH2:32][CH2:31][N:30]([CH3:29])[CH2:35][CH2:34]4)[cH:19][cH:20]3)[s:13]2)[cH:7][cH:8]1

Participants

3

Reactant 2

HCID 11188635[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amineHCID 39146979[4-(4-Methylpiperazin-1-yl)phenyl]thiourea

Product 1

HCID 11773416[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

Sources & evidence

ORD record
ord-131fced0b58842b585ad51f317849dd5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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