2-Chloro-4-fluorobenzoyl chloride → HCID 178430854, compound

HRID 31906Notes

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([Cl:11])[CH:3]=1.ClC1C=C(Cl)C=CC=1C1[C:25]([C:26]2[NH:27][CH:28]=[C:29]([CH3:31])[N:30]=2)=[CH:24][N:23]=[C:22]([NH:32][CH2:33][CH2:34][NH:35][C:36]2[N:41]=[CH:40][C:39]([C:42]#[N:43])=[CH:38][CH:37]=2)[N:21]=1>>[Cl:11][C:4]1[CH:3]=[C:2]([F:1])[CH:10]=[CH:9][C:5]=1[C:6]1[C:25]([C:26]2[NH:27][CH:28]=[C:29]([CH3:31])[N:30]=2)=[CH:24][N:23]=[C:22]([NH:32][CH2:33][CH2:34][NH:35][C:36]2[N:41]=[CH:40][C:39]([C:42]#[N:43])=[CH:38][CH:37]=2)[N:21]=1

Participants

Reactant 2

HCID 27365462-Chloro-4-fluorobenzoyl chloride

HCID 178430853HCID 178430853, compound

Product 1

HCID 178430854HCID 178430854, compound

Procedure

6-[(2-{[4-(2-chloro-4-fluorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]-amino}ethyl)amino]pyridine-3-carbonitrile was prepared from 4-fluoro-2-chlorobenzoyl chloride using the general method for 6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile.

Sources & evidence

ORD record: ord-20e7c1af20d843f5a338f52f8b725b4f
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07425557B2

Reaction notes

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