HCID 178418800, compound → 1-(2,4-Dichlorophenyl)-2-(4-methylimidazol-2-yl)ethan-1-one

HRID 31921Notes

Reaction equation

HRID 31921 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1C=CN[N:12]=1.[CH3:17][C:18]1[N:19]=CN[CH:22]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1[NH:12][CH:17]=[C:18]([CH3:22])[N:19]=1

Participants

3

Reactant 2

HCID 178418800HCID 178418800, compoundHCID 178520323HCID 178520323, compound

Product 1

HCID 1784308761-(2,4-Dichlorophenyl)-2-(4-methylimidazol-2-yl)ethan-1-one

Procedure

Made using the same procedure as for 1-(2,4-dichlorophenyl)-2-pyrazolylethan-1-one except that 4-methylimidazole (3.7 g, 44.8 mmol) was used in place of pyrazole. The crude residue was purified on silica gel (5% MeOH/CH2Cl2) to yield a light yellow solid.

Workup

  1. customThe crude residue was purified on silica gel (5% MeOH/CH2Cl2)
  2. customto yield a light yellow solid

Sources & evidence

ORD record
ord-563adb478c9f459cb0ea45d4f334cec9
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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