Benzimidazole → 2-(Benzimidazolyl)-1-(2,4-dichlorophenyl)ethanone

HRID 31922Notes

Reaction equation

HRID 31922 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1C=CN[N:12]=1.[N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2NC=1>>[N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[NH:12][C:11]=1[CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])=[O:16]

Participants

3

Reactant 2

HCID 5798BenzimidazoleHCID 178520323HCID 178520323, compound

Product 1

HCID 221424812-(Benzimidazolyl)-1-(2,4-dichlorophenyl)ethanone

Procedure

Made using the same procedure as for 1-(2,4-dichlorophenyl)-2-pyrazolylethan-1-one except that benzimidazole (5.3 g, 44.8 mmol) was used in place of pyrazole. The crude residue was purified on silica gel (50% EtOAc/hexanes) to yield a light yellow solid

Workup

  1. customThe crude residue was purified on silica gel (50% EtOAc/hexanes)
  2. customto yield a light yellow solid

Sources & evidence

ORD record
ord-bd36d1a5d5894e99825aa4b6b61487c2
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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