HCID 178418822, compound → HCID 178520385, compound

HRID 31924Notes

Reaction equation

HRID 31924 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1C=CN[N:12]=1.[C:17]1([C:23]2[N:24]=CN[CH:27]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1[NH:12][CH:27]=[C:23]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:24]=1

Participants

3

Reactant 2

HCID 178418822HCID 178418822, compoundHCID 178520323HCID 178520323, compound

Product 1

HCID 178520385HCID 178520385, compound

Procedure

Made using the same procedure as for 1-(2,4-dichlorophenyl)-2-pyrazolylethan-1-one except that 4-phenylimidazole (6.5 g, 44.8 mmol) was used in place of pyrazole. The crude residue was purified on silica gel (50% EtOAc/hexanes) to yield a light yellow solid.

Workup

  1. customThe crude residue was purified on silica gel (50% EtOAc/hexanes)
  2. customto yield a light yellow solid

Sources & evidence

ORD record
ord-dd05c0d5236d4314997aaffbf6f4b05b
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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