Imidazole → 1-(2,4-dichlorophenyl)-2-(1H-imidazol-2-yl)ethanone

HRID 31925Notes

Reaction equation

HRID 31925 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1C=CN[N:12]=1.[NH:17]1[CH:21]=[CH:20]N=C1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1[NH:12][CH:20]=[CH:21][N:17]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 178520323HCID 178520323, compound

Product 1

HCID 221427181-(2,4-dichlorophenyl)-2-(1H-imidazol-2-yl)ethanone

Procedure

Made using the same procedure as for 1-(2,4-dichlorophenyl)-2-pyrazolylethan-1-one except that imidazole (3.1 g, 44.8 mmol) was used in place of pyrazole. The crude residue was purified on silica gel (5% MeOH/CH2Cl2) to yield a light yellow solid.

Workup

  1. customThe crude residue was purified on silica gel (5% MeOH/CH2Cl2)
  2. customto yield a light yellow solid

Sources & evidence

ORD record
ord-5c5570f39cdb405c86851e4f4307b11d
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

Loading…