HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzimidazolyl-1-(2,4-dichlorophenyl)-3(dimethylamino)prop-2-en-1-one → [5-Benzimidazolyl-4-(2,4-dichlorophenyl)pyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzimidazolyl-1-(2,4-dichlorophenyl)-3(dimethylamino)prop-2-en-1-one | HCID 53834601 | — |
| Reactant | HCID 178478900 | HCID 178478900 | — |
| Product | [5-Benzimidazolyl-4-(2,4-dichlorophenyl)pyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine dihydrochloride | HCID 69308291 | — |
Reaction Steps
Made using the same procedure as for [4-(2,4-dichlorophenyl)-5-pyrazolylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine dihydrochloride except that 2-benzimidazolyl-1-(2,4-dichlorophenyl)-3-(dimethylamino)prop-2-en-1-one (XIV, 468 mg, 1.3 mmol) was used and the crude product was purified by recrystallization (CH2Cl2/Et2O/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425557B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-5ef4a6ec51e24330b9fddb1b892d9c5b |
| Source note | uspto-grants-2008_09 |