HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → 2-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,2',4'-Trichloroacetophenone | HCID 20250 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione | HCID 736778 | — |
Reaction Steps
1 mmol of 2,4-dichlorophenacyl chloride in DMF was added drop wise to 2 mmol of phthalimide and 2 mmol of Cs2CO3 in DMF at room temperature for fourteen hours and then the reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The ethyl acetate layer was concentrated and then purified by trituration with diethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425557B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-3e0c078db39545a3a7f4449c39c5a50e |
| Source note | uspto-grants-2008_09 |