反应详情

温度

180 °C

A mixture of 0.113 g (0.29 mmol) of 6-(2,6-dichlorophenyl)-2-methanesulfonyl-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one of Example 39 and 0.50 g (4.10 mmol) of 4-methoxyaniline was heated, with stirring, in a 180° C. oil bath. The resulting solution was heated for 10 minutes. Much of the excess aniline was evaporated at reduced pressure. The remainder was dissolved in 2 mL of ethyl acetate. The crystals that separated from the dark solution were filtered and washed with 2 mL of ethyl acetate, wt 0.102 g.

1. temperaturewas heated
2. temperatureThe resulting solution was heated for 10 minutes
3. customMuch of the excess aniline was evaporated at reduced pressure
4. dissolutionThe remainder was dissolved in 2 mL of ethyl acetate
5. customThe crystals that separated from the dark solution
6. filtrationwere filtered
7. washwashed with 2 mL of ethyl acetate, wt 0.102 g