HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributyl[(methoxymethoxy)methyl]stannane → 1-[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-2-methoxymethoxy-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributyl[(methoxymethoxy)methyl]stannane | HCID 4193592 | — |
| Reactant | 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde | HCID 11245608 | — |
| Product | 1-[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-2-methoxymethoxy-ethanol | HCID 67345152 | — |
Reaction Steps
6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde 10f is treated with tributyl-methoxymethoxymethyl-stannane according to the procedure described in Example 42, Step A to yield compound 101. MS APCI (+) m/z 444, 446 (M+, Br pattern) detected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425637B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-3caf82447437483198f968d83b618e3f |
| Source note | uspto-grants-2008_09 |