Toluene → Loratadine

HRID 320446Notes

Reaction equation

HRID 320446 reaction equation
[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[Cl:1][C:2](=[O:3])[O:4][CH2:5][CH3:6].[Cl:7][c:8]1[cH:9][cH:10][c:11]2[c:12]([cH:29]1)[CH2:13][CH2:14][c:15]1[c:16]([n:17][cH:18][cH:19][cH:20]1)[C:21]2=[C:22]1[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]1>>[C:2](=[O:3])([O:4][CH2:5][CH3:6])[N:25]1[CH2:24][CH2:23][C:22](=[C:21]2[c:11]3[cH:10][cH:9][c:8]([Cl:7])[cH:29][c:12]3[CH2:13][CH2:14][c:15]3[c:16]2[n:17][cH:18][cH:19][cH:20]3)[CH2:27][CH2:26]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 10928Ethyl chloroformateHCID 31843N-Methyldesloratadine

Product 1

HCID 3957Loratadine

Sources & evidence

ORD record
ord-30bb739df3e04a5f89d9a3d7dd462129
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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