Hydrochloric Acid → HCID 68930959, compound

Participants

Reaction Steps

N-(7-Cyano-chroman-4-yl)-3-(naphthalen-2-ylsulfonylamino)-3-phenyl-propionamide (Example 1, Step F) (30 mg, 0.06 mmol) and Pd(OH)2 (6 mg) was added in MeOH (10 mL), followed by adding 1.0 mL of 3.0 M HCl-MeOH. The solution was purged with N2, then sealed with H2 (50 psi) and shaken overnight until the reduction was completed. The solution was filtered, and concentrated to near dryness in vacuo. The crude compound was purified by precipitation in EtOAc-Et2O to provide the HCl salt as a white solid mixture of diastereomer. MS (ESI) 516 (M+H)+.

Provenance & Evidence