tert-Butyl 1,8-diazaspiro(4.5)decane-1-carboxylate → 8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,8-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

HRID 320542Notes

Reaction equation

HRID 320542 reaction equation
[C:29]([CH3:30])([CH3:31])([CH3:32])[O:33][C:34](=[O:35])[N:36]1[CH2:37][CH2:38][CH2:39][C:40]12[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]2.[Cl:1][c:2]1[n:3][c:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([NH:16][CH2:17][CH:18]3[CH2:19][CH2:20]3)[CH2:21][CH2:22]1)[s:10]2>>[Cl:1][c:2]1[n:3][c:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:43]1[CH2:42][CH2:41][C:40]3([N:36]([C:34]([O:33][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:35])[CH2:37][CH2:38][CH2:39]3)[CH2:45][CH2:44]1)[s:10]2

Participants

3

Reactant 2

HCID 34178602tert-Butyl 1,8-diazaspiro(4.5)decane-1-carboxylateHCID 58117134[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine

Product 1

HCID 581170798-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,8-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-f39c28d4f0a3401ca327c72683a9d804
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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