3-(naphthalene-2-sulfonamido)-3-phenylpropionic Acid → N-(4-Cyano-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide

HRID 32057Notes

Reaction equation

HRID 32057 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH:15]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:16][C:17](O)=[O:18])(=[O:13])=[O:12].[NH2:26][CH:27]1[C:35]2[CH:34]=[CH:33][CH:32]=[C:31]([C:36]#[N:37])[C:30]=2[CH2:29][CH2:28]1>>[C:36]([C:31]1[CH:32]=[CH:33][CH:34]=[C:35]2[C:30]=1[CH2:29][CH2:28][CH:27]2[NH:26][C:17](=[O:18])[CH2:16][CH:15]([NH:14][S:11]([C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)(=[O:12])=[O:13])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)#[N:37]

Participants

3

Reactant 2

HCID 36326413-(naphthalene-2-sulfonamido)-3-phenylpropionic AcidHCID 184485541H-Indene-4-carbonitrile, 1-aMino-2,3-dihydro-

Product 1

HCID 68929027N-(4-Cyano-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide

Procedure

N-(4-Cyano-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide was prepared from 3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionic acid ( ) and 1-amino-indan-4-carbonitrile (Step E), using essentially the same procedure described in Example 1, Step F, yielding a white solid. MS (ESI) m/z 496 (M+H)+.

Workup

  1. customyielding a white solid

Sources & evidence

ORD record
ord-5c61ef568dd94b52b0b73ba6572147d2
Source dataset
uspto-grants-2008_09
Patent number
US07425631B2

Reaction notes

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