Dimethylamine → n-(5-Dimethylaminomethyl-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide

HRID 32061Notes

Reaction equation

HRID 32061 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH:8]([NH:12][C:13](=[O:36])[CH2:14][CH:15]([NH:22][S:23]([C:26]1[CH:35]=[CH:34][C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=1)(=[O:25])=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:7][CH2:6]2)=O.[NH:37]([CH3:39])[CH3:38]>>[CH3:38][N:37]([CH2:1][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH:8]([NH:12][C:13](=[O:36])[CH2:14][CH:15]([NH:22][S:23]([C:26]1[CH:35]=[CH:34][C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=1)(=[O:24])=[O:25])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:7][CH2:6]2)[CH3:39]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 86598501N-(5-formyl-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide

Product 1

HCID 68929642n-(5-Dimethylaminomethyl-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide

Procedure

The title compound was prepared from N-(5-formyl-indan-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide (Step G) and Me2NH, using essentially the same procedure described in Example 1, Step H, yielding a white solid. MS (ESI) m/z 528 (M+H)+.

Workup

  1. customyielding a white solid

Sources & evidence

ORD record
ord-2ba3075d6dc94821b2993bd266328ebc
Source dataset
uspto-grants-2008_09
Patent number
US07425631B2

Reaction notes

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