3-(naphthalene-2-sulfonamido)-3-phenylpropionic Acid → N-(6-cyano-1,2,3,4-tetrahydro-naphthalen-1-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide
Reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH:15]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:16][C:17](O)=[O:18])(=[O:13])=[O:12].[NH2:26][CH:27]1[CH2:36][CH2:35][CH2:34][C:33]2[CH:32]=[C:31]([C:37]#[N:38])[CH:30]=[CH:29][C:28]1=2>>[C:37]([C:31]1[CH:32]=[C:33]2[C:28](=[CH:29][CH:30]=1)[CH:27]([NH:26][C:17](=[O:18])[CH2:16][CH:15]([NH:14][S:11]([C:2]1[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=1)(=[O:13])=[O:12])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:36][CH2:35][CH2:34]2)#[N:38]Participants
3
Procedure
The title compound was prepared from 3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionic acid and 5-amino-5,6,7,8-tetrahydro-naphthalen-2-carbonitrile (Step E) by a method similar to that described in Example 1, Step F. MS (−APCI m/z): 508 (M−H)−.
Sources & evidence
- ORD record
- ord-0aeabd0cbc3542e3ace25631cd30c0d4
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07425631B2
Reaction notes
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