Dichloromethane → 2-trimethylsilylethyl N-[4-bromo-1'-[3-[2-(trifluoromethyl)phenyl]prop-2-enoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]carbamate

HRID 320860Notes

Reaction equation

HRID 320860 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[C:9]1([CH2:8][CH:7]2[NH:16][C:17]([O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.[Cl:65][CH2:66][Cl:67].[F:26][C:27]([c:28]1[c:29]([CH:30]=[CH:31][C:32](=[O:33])[OH:34])[cH:35][cH:36][cH:37][cH:38]1)([F:39])[F:40].[P-:41]([F:42])([F:43])([F:44])([F:45])([F:46])[F:47].[n:48]1([O:49][C:50]([N:51]([CH3:52])[CH3:53])=[N+:54]([CH3:55])[CH3:56])[c:57]2[n:58][cH:59][cH:60][cH:61][c:62]2[n:63][n:64]1>>[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[C:9]1([CH2:8][CH:7]2[NH:16][C:17]([O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:11][CH2:12][N:13]([C:32]([CH:31]=[CH:30][c:29]2[c:28]([C:27]([F:26])([F:39])[F:40])[cH:38][cH:37][cH:36][cH:35]2)=[O:33])[CH2:14][CH2:15]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 749393-(2-(Trifluoromethyl)phenyl)-2-propenoic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 67224539(+/-)-2-(Trimethylsilyl)ethyl 7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-ylcarbamate

Product 1

HCID 672230152-trimethylsilylethyl N-[4-bromo-1'-[3-[2-(trifluoromethyl)phenyl]prop-2-enoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]carbamate

Sources & evidence

ORD record
ord-1732751aaad84db4b8e05e0b9f6de401
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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