HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 3-(Naphthalen-2-yl-sulfonylamino)-N-(1-methyl-2,2-dioxo-7-piperidin-1-ylmethyl-1,2,3,4-tetrahydro-2lambda6-benzo[c][1,2]thiazin-4-yl)-3-phenyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | HCID 68926983 | HCID 68926983 | — |
| Product | 3-(Naphthalen-2-yl-sulfonylamino)-N-(1-methyl-2,2-dioxo-7-piperidin-1-ylmethyl-1,2,3,4-tetrahydro-2lambda6-benzo[c][1,2]thiazin-4-yl)-3-phenyl-propionamide | HCID 68928653 | — |
Reaction Steps
The title compound was prepared from N-(7-hydroxymethyl-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazin-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide (Example 12, Step D) via its mesylate and addition of piperidine by a method similar to that described in Example 12, Step E. MS (+ESI, m/z): 647 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425631B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-e712505069774998bf9341b5d9f346b9 |
| Source note | uspto-grants-2008_09 |