5-Aminoisoquinoline → N-Isoquinolin-5-yl-1-(5-trifluoromethylpyrid-2-yl)-piperidine-4-carboxamide
Reaction equation
[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][CH:12]([C:15](=[O:16])[OH:17])[CH2:13][CH2:14]2)[n:7][cH:8]1)([F:18])[F:19].[NH2:20][c:21]1[c:22]2[cH:23][cH:24][n:25][cH:26][c:27]2[cH:28][cH:29][cH:30]1>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][CH:12]([C:15](=[O:17])[NH:20][c:21]3[c:22]4[cH:23][cH:24][n:25][cH:26][c:27]4[cH:28][cH:29][cH:30]3)[CH2:13][CH2:14]2)[n:7][cH:8]1)([F:18])[F:19]Participants
3
Sources & evidence
- ORD record
- ord-c009e3a58cae4fef99e26c2a7bff418f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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