Di-tert-butyl dicarbonate → (6-Hydroxymethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamic acid tert-butyl ester

Participants

Reaction Steps

To a solution of (5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-methanol (2.0 g, 11.28 mmol) in CH2Cl2 (20 mL) was added (BOC)2O (2.7 g, 12.41 mmol). The resulting mixture was stirred at RT under N2 gas for 2 h. Reaction mixture was quenched with sat. NH4Cl, the organic layer was isolated and washed with water, brine, dried over MgSO4 and evaporated in vacuo to give the final product. MS m/z: 278.12 (M+H). Calc'd. for C16H23NO3-277.36.

Provenance & Evidence