1,2-Dichloroethane → N-(6-acetyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-3-(4-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide

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Reaction Steps

A mixture of (6-acetyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamic acid tert-butyl ester (Step e, 543 mg, 1.88 mmol, 1.0 eq) in HCl/EtOAc (4.7 M, 20 mL) was stirred at RT for 200 min. The solvent was removed with a rotary evaporator, and the resulting 1-(5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone hydrogen chloride was dried in vacuo. A mixture of 1-(5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone hydrogen chloride, 3-(4-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionic acid (882 mg, 2.26 mmol, 1.2 eq), EDC (Aldrich, 649 mg, 3.38 mmol, 1.8 eq), HOBt (Aldrich, 51 mg, 0.376 mmol, 0.2 eq) and DIEA (Aldrich, 486 mg, 3.76 mmol, 2.0 eq) in CH2Cl2 (20 mL) and DMF (5 mL) was stirred at RT overnight. The reaction was quenched with H2O (100 mL). The crude was extracted with CH2Cl2 (150 mL×3). The extract phase was washed with saturated NaCl, dried over Na2SO4, filtered and concentrated. Flash column chromatography (silica gel, 0-5% MeOH—CH2Cl2) afforded the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 563 (M+1).

Provenance & Evidence