(3-Bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl ester → {2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-cyclopropylmethoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

HRID 321176Notes

Reaction equation

HRID 321176 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([N:10]([CH2:11][c:12]1[c:13]([B:22]2[O:23][C:24]([CH3:25])([CH3:26])[C:27]([CH3:28])([CH3:29])[O:30]2)[cH:14][cH:15][c:16]([C:18]([F:19])([F:20])[F:21])[cH:17]1)[CH2:31][CH3:32])=[O:33].[CH2:34]([CH3:35])[O:36][C:37]([CH2:38][c:39]1[cH:40][c:41]([Br:50])[c:42]([O:45][CH2:46][CH:47]2[CH2:48][CH2:49]2)[cH:43][cH:44]1)=[O:51]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([N:10]([CH2:11][c:12]1[c:13](-[c:41]2[cH:40][c:39]([CH2:38][C:37]([O:36][CH2:34][CH3:35])=[O:51])[cH:44][cH:43][c:42]2[O:45][CH2:46][CH:47]2[CH2:48][CH2:49]2)[cH:14][cH:15][c:16]([C:18]([F:19])([F:20])[F:21])[cH:17]1)[CH2:31][CH3:32])=[O:33]

Participants

3

Reactant 2

HCID 58149222(3-Bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl esterHCID 66603618(Ethyl)[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethylbenzyl]carbamic acid benzyl ester

Product 1

HCID 66607617{2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-cyclopropylmethoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

Sources & evidence

ORD record
ord-860decbf7ecb479a92e1ab8e2d4f4b6d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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