2-(Bromomethyl)-5-(trifluoromethyl)furan → 1'-[(6-methoxypyridin-3-yl)methyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 321479Notes

Reaction equation

HRID 321479 reaction equation
[Br:21][CH2:22][c:23]1[o:24][c:25]([C:26]([F:27])([F:28])[F:29])[cH:30][cH:31]1.[CH3:1][c:2]1[cH:3][cH:4][c:5]([S:6]([O:7][CH2:12][c:13]2[cH:14][n:15][c:16]([O:19][CH3:20])[cH:17][cH:18]2)(=[O:8])=[O:9])[cH:10][cH:11]1.[CH3:53][C:54]1([CH3:55])[CH2:56][O:57][c:58]2[cH:59][c:60]3[c:73]([cH:74][c:75]21)[C:63]1([CH2:62][O:61]3)[c:64]2[c:65]([cH:66][cH:67][cH:68][cH:69]2)[NH:70][C:71]1=[O:72].[NH:32]1[C:33](=[O:52])[C:34]2([CH2:35][O:36][c:37]3[c:38]2[cH:39][c:40]2[c:41]([cH:45]3)[O:42][CH2:43][O:44]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][c:51]21>>[CH2:12]([c:13]1[cH:14][n:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[N:32]1[C:33](=[O:52])[C:34]2([CH2:35][O:36][c:37]3[c:38]2[cH:39][c:40]2[c:41]([cH:45]3)[O:42][CH2:43][O:44]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][c:51]21

Participants

5

Reactant 4

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 53375495spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-oneHCID 592634705,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1H)-oneHCID 86609006(6-Methoxypyridin-3-yl)methyl 4-methylbenzenesulfonate

Product 1

HCID 592634711'-[(6-methoxypyridin-3-yl)methyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-8aa64189c0af4543a13eefa89d9aa40e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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