Pyridine → HCID 131722470, compound

Participants

Reaction Conditions

Reaction Steps

50g of poly(hydroxystyrene/t-butoxycarbonylmethoxystyrene/morpholinylcarbonylmethoxystyrene) where 8.4% of hydroxy groups in polyhydroxystyrene was substituted into t-butoxycarbonylmethoxy group and 5% of hydroxy groups into morpholinylcarbonylmethoxy group, so obtained from Synthesis example 3, was dissolved in 500 ml dimethyl formamide. With the addition of p-toluene sulfonic acid in catalytic amount, the reacting mixture was stirred at 20° C., followed by the addition of ethylvinyl ether (14 g). After reaction for 1 hour, the mixture was neutralized with pyridine, followed by dropwise adding into 5 L water to obtain a white solid. The solid, so formed, was filtered off, washed with distilled water for dehydration and dissolved again in acetone. Then, the reacting solution dropwise added into 5 L water for filtration and washed, for dehydration and drying. Thus, a resin, so obtained, was 52g of poly(hydroxystyrene/ethoxyethoxystyrene/t-butoxycarbonylmethoxystyrene/morpholinocarbonyl lmethoxystyrene) having the weight average molecular weight of 14,400 as polystyrene, in which 16% of hydroxy groups in polyhydroxystyrene was substituted into ethoxyethoxy group, 8.4% of hydroxy groups into t-butoxycarbonylmethoxy group and 5% of hydroxy groups into morpholinylcarbonylmethoxy group.

Provenance & Evidence