反应详情

To a solution of 3,4,5-trimethoxybenzenesulfonyl chloride (500 mg, 1.88 nmol) in methanol (10 mL) was added 3-hydroxy-4-methoxyaniline (523 mg, 3.76 mmol) at ambient temperature. After stirring for 1 h, the reaction mixture was concentrated and the crude residue was purified by chromatography over silica to afford 430 mg (62%) of product as fine white needles, m.p. 145-146° C.

1. concentrationthe reaction mixture was concentrated
2. customthe crude residue was purified by chromatography over silica