Potassium Hydroxide → HCID 178487784, compound

Participants

Reaction Steps

A mixture of ethyl 2-[5-Fluoro-2-(3,4,5-trimethoxyphenyl)benzimidazolyl]acetate (11.99 mmole, 4.65 g) and potassium hydroxide (40 mmole, 2.24 g) in ethanol (80 ml) is stirred at reflux for 2 hours. The solvent is evaporated and the residue is charged with water (100 ml) and ether (100 ml). The aqueous layer is washed with ether (2×50 ml) and charged with concentrated HCl (pH 1). After 24 hours the colorless precipitate is filtered off and dried in vacuo (R1=(CH2)x—C(O)—OR4, x=1, R2=3,4,5-trimethoxyphenyl, R3=F, R4=hydrogen, n=1).

Provenance & Evidence