Hydrochloric Acid → HCID 18315473, compound

Participants

Reaction Steps

Ethanol (80 ml) and 10% sodium hydroxide aqueous solution (37 g) are added to 2-benzyl-1-(2,4-dichlorobenzyl)-6-ethoxycarbonylbenzimidazole (0.48 g) (example 12), and the solution is refluxed for 4 hours. After the reaction solution is cooled, its acidity is adjusted to pH 6 with 10% hydrochloric acid. The sediment is gathered, is washed with water, is dried under reduced pressure, and thus, 2-benzyl-6-carboxy-1-(2,4-dichlorobenzyl)benzimidazole (0.35 g) is obtained.

Provenance & Evidence