Hydrochloric Acid → HCID 18680830, compound

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Reaction Steps

To an ethanol (4 ml) solution of 2-benzyl-6-ethoxycarbonyl-1-methylbenzimidazole (0.340 g) (example 10), 5% sodium hydroxide aqueous solution (2.8 g) is added, and the solution is refluxed for 1.5 hours. The solution is made acidic using 1N hydrochloric acid, and is concentrated under reduced pressure. Ethanol is added to the residue and organic materials are extracted. The ethanol is removed under reduced pressure and thus, 2-benzyl-6-carboxy-1-methylbenzimidazole hydrochloride (0.30 g) is obtained. 1H-NMR (DMSO-d6, δ): 4.00 (3H, s), 4.62 (2H, s), 7.33 (1H, m), 7.35-7.45 (4H, m), 7.83 (1H, d, J=8.4 Hz), 8.06 (1H, d, J=8.4 Hz), 8.42 (1H, s), 13.3 (1H, br s).

Provenance & Evidence